In STA® -Liatest® D-Di Plus, the addition of a blocking agent improves the analytical and diagnostic performances of the assay by minimizing interferences to heterophilic antibodies, including rheumatoid factors (RF) and Human Anti-Mouse Antibodies (HAMA).
Less Interferences for more efficacy
Immunoassays, which are commonly used in the diagnostic testing, may be prone to interferences with heterophilic antibodies, when present in patient plasmas. The prevalence of these interferences with D-Dimer assays in the diagnosis of VTE is low but may cause an overestimation of the result.
STA® -Liatest® D-Di Plus has been developed to minimize these interferences:
- HAMA: buffer contains a blocking agent
- RF: No interference up to 1,000 IU/mL
By minimizing the interferences from heterophilic antibodies, STA® -Liatest® D-Di Plus has been designed to show improved specificity for even more efficacy.
More Performances for more efficiency
- Validated:
STA® -Liatest® D-Di Plus is intended for use for aid in the diagnosis of Deep Venous Thrombosis (DVT) and Pulmonary Embolism (PE) - Adapted to STAT (available 24/7):
- Precalibrated
- Stable 15 days on board on STA® line analysers
- Easy-to-use:
Automated, ready-to-use reagent with standardised results across Stago analysers - Reliable:
Low coefficients of variations (CV) across international proficiency testing program reports
Select the best D-Dimer test for cost-effectiveness and safety.
STA® -Liatest® D-Di has been clinically validated in outcome studies of over 4,000 patients with suspected DVT and PE to be used to safely aid in the diagnosis of VTE.
Using the 0.5 μg/mL (FEU) threshold in conjunction with a pre-test probability assessment, the STA® -Liatest® D-Di has consistently produced low CVs across proficiency program specimens and has been used safely for more than 10 years. STA® -Liatest® D-Di is currently the most frequently used D-Dimer test on the market.
Perfectly correlated with STA®-Liatest® D-Di and thanks to the addition of a blocking agent, STA® -Liatest® D-Di Plus benefits from all the references and widely known advantages of STA®-Liatest® D-Di.
Key features:
| Reporting units | µg/mL FEU | |
|
Assay range |
0.27-20 µg/mL FEU | |
| Cut-off value | 0.5 µg/mL FEU | |
| Negative Predictive Value (NPV) | 95-100% | |
| Repetability** | 6.27% (at 0.67) | 2,23% (at 2.20) |
| Within-lab precision** | 7.31% (at 0.67) | 3,86% (at 2.20) |
| Calibration | Unique precalibration on STA analysers | |
| TAT | <7 min. | |
| Interferences to RF | eliminated up to 1,000 IU/mL | |
| Interferences to HAMA | minimized | |
| Reagents | Controls | Disposables |
|---|---|---|
| STA®-Liatest® D-Di Plus | STA®-Liatest® Control N+P | STA®-Mini Reducer |
| Cat. Nr. 00662 | Cat. Nr. 00526 | Cat. Nr. 00797 |
| 6 x 5 mL of Reagent 1 (Buffer) 6 x 6 mL of Reagent 2 (Latex) |
12 x 1 mL of Reagent 1 (STA® -Liatest® Control N) 12 x 1 mL of Reagent 2 (STA® -Liatest® Control P) |
1 box of 100 STA-Mini Reducer |
* Available depending upon the country
** Calculated from Standard Deviation (SD) in STA® -Liatest® D-Di Plus package insert